Download Arterial Remodeling: A Critical Factor in Restenosis by Seymour Glagov, Hisham S. Bassiouny (auth.), Antoine Lafont, PDF

By Seymour Glagov, Hisham S. Bassiouny (auth.), Antoine Lafont, Eric J. Topol (eds.)

Angioplasty has thoroughly remodeled the remedy of coronary artery disorder and is customary, with greater than 800,000 tactics played around the globe in step with yr. even though, the keenness for angioplasty is shadowed by way of restenosis, which continues to be a serious challenge after the method, leading to medical recurrence in over a 3rd of sufferers. lately, the mechanisms of restenosis were thoroughly reappraised with an enriched realizing that the unique proposal of neointimal hyperplasia is probably not accounting for the majority of the matter.
there's a determined have to heighten figuring out of the transforming technique on the molecular, mobile, and arterial point. Vascular home improvement is a good demonstrated inspiration within the box of atherosclerosis and high blood pressure, yet merely in recent times has its applicability to the sector of restenosis develop into pivotal. as a result, the editors perceived the necessity to gather the 1st booklet devoted to the idea that of coronary artery home improvement in restenosis, with the intention to basically assessment the experiments resulting in the transforming speculation and combine this with the neointimal hyperplasia (tumor) version for the improvement of the restenotic lesion.
The authors of this booklet current their adventure to facilitate the certainty of the mechanisms for coronary restenosis and transforming. many of the experimental versions, scientific concerns, and easy mechanisms are reviewed intimately, leading to a clean method of a vexing medical challenge. Arterial home improvement: A serious think about Restenosis could be worthy to the health care professional and trainee who've an curiosity in restenosis, and particularly within the significant pathophysiologic strategy which determines the destiny of arterial therapeutic in sufferers following percutaneous coronary revascularization. it's was hoping that this publication will lay the basis for more suitable remedies that may lessen the opportunity of constrictive home improvement and increase the long term efficacy of non-surgical coronary revascularization within the future.

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Extra resources for Arterial Remodeling: A Critical Factor in Restenosis

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Pharmacological prevention of restenosis after coronary angioplasty: review of randomized clinical trials. Coronary Artery Dis. 1993;4:232-242. 3. Currier JW, Faxon DP. Restenosis after percutaneous transluminal coronary angioplasty: have we been aiming at the wrong target? J Am Coli Cardiol 1995;25:516-20. 4. O'Brien ER, Alpers CE, Stewart OK, et al. Proliferation in primary and restenotic coronary atherectomy tissue: implications for antiproliferative therapy. Circ Res 1993;73:223-31. 5. Mintz OS, Popma JJ, Pichard AD, et al.

28 REFERENCES 1. Faxon DP, Currier JW. Prevention ofpost-PTCA restenosis. Ann NY Acad Sci 1995;748:419-28 2. Post MJ, Borst C, Kuntz RE. The relative importance of arterial remodeling compared with intimal hyperplasia in lumen renarrowing after balloon angioplasty. A study in the normal rabbit and the hypercholesterolemic Yucatan micropig. Circulation 1994;89:2816-21 3. Lafont A, Ouzman LA, Whitlow PL, Goormastic M, Cornhill JF, Chisolm OM. Restenosis after experimental angioplasty. Intimal, medial and adventitial changes associated with constrictive remodeling.

Bassiouny The University of Chicago, Division of the Biological Sciences, Department of Pathology, Chicago, Illinois, USA The nature of restenosis at sites of direct intervention designed to restore patency to obstructed atherosclerotic arteries remains an enigma. Despite evidence that the occlusive intimal reaction is characterized by migration and proliferation of smooth muscle cells, clinical administration of known inhibitors of smooth muscle cell migration and/or proliferation has not altered the 30-40% incidence of reocclusion within a few months 1-5.

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