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By E. B. Smith, S. Björkerud, R. H. More, D. Sinapius, G. S. Berenson, W. Insull (auth.), G. Schettler, A. Weizel (eds.)

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Most often it is composed largely of fibrin, but microthrombi with a considerable core of platelets or predominantly consisting of platelets may be also found. Some of such microthrombi are covered by endothelium and may be in various stages of "contraction" of their fibrin mass and organization. Microthrombi may extend over somewhat larger area of the intima, but most commonly are focal. They may be found at all ages, even in small children, and over microscopically unaltered intima (Haust and More, 1960).

1 illustrates changes of the total MPS with the degree and varying types of atherosclerotic lesions and indicates a progressive increase with the extensiveness of fatty streaks and perhaps fibrous plaques. However, with more advanced disease and complicated lesions there is an actual decrease in the MPS content. , 1971). Studies of the specific changes of MPS indicate alterations occur primarily with chondroitin sulfates and heparin sulfate. Fig. 2 shows the general direction of changes of MPS with Ca++, collagen and lipids.

A large proportion of regions with intact endothelium do not stain for lipid at all. Furthermore, the calcified region present (Fig. 4) is covered with intact endothelium, as is the case for mechanically induced experimental calcified lesions (Fig. 3, I 2; Bjorkerud and Bondjers, 1971). The human lesion shown in Fig. 4 would probably be classified as a fatty streak in traditional pathological terms. However, it is possible to discriminate different characteristic parts of this lesion which are similar to those present in the experimental lesion following a superficial injury with large area (Fig.

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